Wednesday, May 13, 2009

Methyl cellulose


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(Redirected from Methylcellulose)

Methyl cellulose

Other names

Cellulose, methyl ether; methylated cellulose; methylcellulose; E461

Identifiers

CAS number

9004-67-5

Properties

Molecular formula

variable

Molar mass

variable

Except where noted otherwise, data are given formaterials in their standard state(at 25, 100kPa)Infobox references

Methyl cellulose (or methylcellulose) is a chemical compound derived from cellulose. It is a hydrophilic white powder in pure form and dissolves in cold (but not in hot) water, forming a clear viscous solution or gel. It is sold under a variety of trade names and is used as a thickener and emulsifier in various food and cosmetic products, and also as a treatment of constipation. Like cellulose, it is not digestible, not toxic, and not allergenic.

Contents

1 Chemistry

2 Solubility and temperature

3 Uses

3.1 Stem cell differentiation

3.2 Scientifically Advanced Cookery

3.3 Thickener and emulsifier

3.4 Treatment of constipation

3.5 Lubricant

3.6 Artificial tears and saliva

3.7 Bacterial Motility Inhibitor

3.8 Paper and textile sizing

3.9 Glue and binder

3.10 Construction materials

3.11 Cell culture/virology

3.12 Nutritional Supplement Capsules

3.13 Special effects

4 See also

5 References

6 External links


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Chemistry

Chemically, methyl cellulose is a methyl ether of cellulose, arising from substituting the hydrogen atoms of some of cellulose's hydroxyl groups -OH with methyl groups -CH3, forming -OCH3 groups.

Different kinds of methyl cellulose can be prepared depending on the number of hydroxyl groups so substituted. Cellulose is a polymer consisting of numerous linked glucose molecules, each of which exposes three hydroxyl groups. The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose. The theoretical maximum is thus a DS of 3.0, however more typical values are 1.3 - 2.6.

Different methyl cellulose preparations can also differ in the average length of their polymer backbones.

Methyl cellulose does not occur naturally and is synthetically produced by heating cellulose with caustic solution (e.g. a solution of sodium hydroxide) and treating it with methyl chloride.

Solubility and temperature

Methyl cellulose dissolves in cold water. Higher DS-values result in lower solubility, because the polar hydroxyl groups are masked. The chemical is not soluble in hot water, which has the paradoxical effect that heating a saturated solution of methyl cellulose will turn it solid, because methyl cellulose will precipitate out. The temperature at which this occurs depends on DS-value, with higher DS-values giving lower precipitation temperatures.

Preparing a solution of methyl cellulose with cold water is difficult however: as the powder comes into contact with water, a gluey layer forms around it, and the inside remains dry. A better way is to first mix the powder with hot water, so that the methyl cellulose particles are well dispersed in the water, and cool down this dispersion while stirring, leading to the dissolution of those particles.

Uses

Methyl cellulose has an extremely wide range of uses, of which several are described below.

Stem cell differentiation

Methylcellulose is used in the most common approaches to quantify multi-lineage- or single lineage-committed hematopoietic progenitors, called colony-forming cells (CFCs) or colony-forming units (CFUs), in combination with culture supplements that promote their proliferation and differentiation and allow the clonal progeny of a single progenitor cell to stay together and thus form a colony of more mature cells. MethoCult is one such methylcellulose-based media.

Scientifically Advanced Cookery

Methyl cellulose, as a gel, has the unique property of setting when hot and melting when cold. This technique is currently being developed at the University of Nottingham.

Thickener and emulsifier

Methyl cellulose is often added to hair shampoos, tooth pastes and liquid soaps, to generate their characteristic thick consistency. This is also done for foods, for example ice cream or croquette. Methyl cellulose is also an important emulsifier, preventing the separation of two mixed liquids.

The E number of methyl cellulose as food additive is E461.

Treatment of constipation

When eaten, methyl cellulose is not absorbed by the intestines but passes through the digestive tract undisturbed. It attracts large amounts of water into the colon, producing a softer and bulkier stool. It is used to treat constipation, diverticulosis, hemorrhoids and irritable bowel syndrome. It should be taken with sufficient amounts of...(and so on)
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